Today, biologists and engineers can start companies with little more than an idea. Rather than giving away most of the equity through venture-builds from the get-go, founders can now pursue their relentless ambitions and be rewarded accordingly. There is no longer a need for supervision from ‘people-that-have-been-there-before’. Of course, experience is essential, but this can be acquired by hiring the right people early on. This change in philosophy — founder-led, idea-driven — has brought a change in the origin of biotech companies.